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BET Bromodomains Focused Library

Bromodomains are acetyl-lysine recognition modules of a diverse group of proteins that play crucial role in chromatin organization and regulation of gene transcription. Proteins that contain bromodomains have been involved in the development of a large variety of diseases. Bromodomain and extra-terminal (BET) proteins, which belong to a class of proteins collectively called epigenetic “readers”, have recently emerged as prospective drug targets for treatment of cancers, inflammatory diseases, and other medical conditions.

ROR Nuclear Receptors Focused Library

Retinoic acid receptor-related orphan receptors (RORs) alpha, beta, and gamma play critical roles in a variety of physiological processes, which include regulation of metabolism, development and immunity as well as the circadian rhythm. Several reports have presented evidence for a potential role of RORs in pathologies such as osteoporosis, several autoimmune diseases, asthma, cancer, and obesity. This stimulated the development of RORs synthetic ligands and opened up the possibility of chemotherapeutic intervention for these receptors.