Focused On-demand Libraries - Receptor.AI Collaboration


Explore the Potential with AI-Driven Innovation

Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.


We carefully select specific compounds from a vast collection of over 60 billion molecules in virtual chemical space. Reaxense helps in synthesizing and delivering these compounds.


The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.


We utilise our cutting-edge, exclusive workflow to develop focused libraries.


 

Fig. 1. The screening workflow of Receptor.AI

Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.


Key features that set our library apart include:


  • The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.

  • The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.

  • With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.

  • Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.


PARTNER
Receptor.AI
 
UPACC
O94829

UPID:
IPO13_HUMAN

ALTERNATIVE NAMES:
Karyopherin-13; Ran-binding protein 13

ALTERNATIVE UPACC:
O94829; D3DPY4; Q5T4X3; Q7LC04; Q96HS3; Q9H8N3; Q9UFR1

BACKGROUND:
Importin-13 plays a critical role in the cellular import and export mechanisms, serving as a receptor for nuclear localization signals and mediating the nuclear import of key proteins such as UBC9 and the RBM8A/MAGOH complex. Its function extends to the nuclear export of eIF-1A, highlighting its importance in maintaining cellular function and protein localization. The protein operates through a complex mechanism involving the Ran-GTPase system, ensuring the precise directionality and regulation of nuclear-cytoplasmic transport.

THERAPEUTIC SIGNIFICANCE:
Exploring the functionalities of Importin-13 offers a promising pathway to uncover novel therapeutic interventions.

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