Focused On-demand Libraries - Receptor.AI Collaboration


Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.


We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by Reaxense.


The library features a range of promising modulators, each detailed with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Plus, each compound is presented with its ideal docking poses, affinity scores, and activity scores, ensuring a thorough insight.


We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.


 

Fig. 1. The screening workflow of Receptor.AI

It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.


Our library distinguishes itself through several key aspects:


  • The Receptor.AI platform integrates all available data about the target protein, including past experiments, literature data, known ligands, structural information and more. This consolidated approach maximises the probability of prioritising highly relevant compounds.

  • The platform uses sophisticated molecular simulations to identify possible binding sites so that the compounds in the focused library are suitable for discovering allosteric inhibitors and the binders for cryptic pockets.

  • The platform integrates over 50 highly customisable AI models, which are thoroughly tested and validated on a multitude of commercial drug discovery programs and research projects. It is designed to be efficient, reliable and accurate. All this power is utilised when producing the focused libraries.

  • In addition to producing the focused libraries, Receptor.AI provides services and end-to-end solutions at every stage of preclinical drug discovery. The pricing model is success-based, which reduces your risks and leverages the mutual benefits of the project's success.


PARTNER
Receptor.AI
 
UPACC
P16083

UPID:
NQO2_HUMAN

ALTERNATIVE NAMES:
NRH dehydrogenase [quinone] 2; NRH:quinone oxidoreductase 2; Quinone reductase 2

ALTERNATIVE UPACC:
P16083; B2R492; Q5TD04

BACKGROUND:
The enzyme Ribosyldihydronicotinamide dehydrogenase [quinone], with alternative names such as NRH dehydrogenase [quinone] 2, serves as a cornerstone in both detoxification pathways and biosynthetic processes. It is instrumental in the reduction of quinones and plays a key role in the synthesis of vital components such as prothrombin, through the vitamin K-dependent gamma-carboxylation of glutamate residues.

THERAPEUTIC SIGNIFICANCE:
Exploring the functionalities of Ribosyldihydronicotinamide dehydrogenase [quinone] unveils new avenues for the development of innovative therapeutic approaches.

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