Focused On-demand Library for Antigen peptide transporter 2

Details

Focused On-demand Libraries - Receptor.AI Collaboration


Explore the Potential with AI-Driven Innovation

This comprehensive focused library is produced on demand with state-of-the-art virtual screening and parameter assessment technology driven by Receptor.AI drug discovery platform. This approach outperforms traditional methods and provides higher-quality compounds with superior activity, selectivity and safety.


We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by Reaxense.


Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.


We employ our advanced, specialised process to create targeted libraries for enzymes.


 

Fig. 1. The screening workflow of Receptor.AI

It includes comprehensive molecular simulations of the catalytic and allosteric binding pockets and the ensemble virtual screening accounting for their conformational mobility. In the case of designing modulators, the structural changes induced by reaction intermediates are taken into account to leverage activity and selectivity.


Our library stands out due to several important features:


  • The Receptor.AI platform compiles comprehensive data on the target protein, encompassing previous experiments, literature, known ligands, structural details, and more, leading to a higher chance of selecting the most relevant compounds.

  • Advanced molecular simulations on the platform help pinpoint potential binding sites, making the compounds in our focused library ideal for finding allosteric inhibitors and targeting cryptic pockets.

  • Receptor.AI boasts over 50 tailor-made AI models, rigorously tested and proven in various drug discovery projects and research initiatives. They are crafted for efficacy, dependability, and precision, all of which are key in creating our focused libraries.

  • Beyond creating focused libraries, Receptor.AI offers comprehensive services and complete solutions throughout the preclinical drug discovery phase. Our success-based pricing model minimises risk and maximises the mutual benefits of the project's success.

PARTNER
Receptor.AI
 
UPACC
Q03519

UPID:
TAP2_HUMAN

ALTERNATIVE NAMES:
ATP-binding cassette sub-family B member 3; Peptide supply factor 2; Peptide transporter PSF2; Peptide transporter TAP2; Peptide transporter involved in antigen processing 2; Really interesting new gene 11 protein

ALTERNATIVE UPACC:
Q03519; B0V2J8; O95410; Q53FI6; Q5HY71; Q96PT8; Q9UQ83

BACKGROUND:
The Antigen peptide transporter 2, known for its role in antigen processing, is essential for immune surveillance. By transporting peptides for MHC class I molecule loading, it ensures the immune system can recognize and eliminate infected cells. Its alternative names, including Peptide transporter involved in antigen processing 2, reflect its critical function in adaptive immunity.

THERAPEUTIC SIGNIFICANCE:
Understanding the role of Antigen peptide transporter 2 could open doors to potential therapeutic strategies. Its involvement in Bare lymphocyte syndrome 1 highlights the importance of this protein in maintaining immune homeostasis and presents a unique opportunity for developing targeted therapies to enhance immune responses.

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