Focused On-demand Libraries - Receptor.AI Collaboration


Explore the Potential with AI-Driven Innovation

The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.


We pick out particular compounds from an extensive virtual database of more than 60 billion molecules. The preparation and shipment of these compounds are facilitated by Reaxense.


Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.


Our top-notch dedicated system is used to design specialised libraries for enzymes.


 

Fig. 1. The screening workflow of Receptor.AI

It includes in-depth molecular simulations of both the catalytic and allosteric binding pockets, with ensemble virtual screening focusing on their conformational flexibility. For modulators, the process includes considering the structural shifts due to reaction intermediates to boost activity and selectivity.


Key features that set our library apart include:


  • The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.

  • The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.

  • With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.

  • Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.


PARTNER
Receptor.AI
 
UPACC
Q8TCJ2

UPID:
STT3B_HUMAN

ALTERNATIVE NAMES:
Source of immunodominant MHC-associated peptides homolog

ALTERNATIVE UPACC:
Q8TCJ2; Q96JZ4; Q96KY7

BACKGROUND:
The protein STT3B, a key component of the oligosaccharyl transferase complex, is instrumental in the N-glycosylation pathway, ensuring the transfer of glycan moieties to target proteins. This process is vital for protein maturation and function, affecting numerous cellular mechanisms. STT3B's unique ability to modify proteins both during and after translation underscores its significance in cellular homeostasis and development.

THERAPEUTIC SIGNIFICANCE:
Malfunctions in STT3B are directly associated with Congenital disorder of glycosylation 1X, characterized by a spectrum of clinical manifestations due to improper protein glycosylation. Exploring the intricacies of STT3B's function offers a promising avenue for the development of novel therapeutic approaches aimed at correcting glycosylation defects, potentially revolutionizing treatment paradigms for related disorders.

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