Focused On-demand Libraries - Receptor.AI Collaboration


Explore the Potential with AI-Driven Innovation

Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.


Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by Reaxense.


Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.


We utilise our cutting-edge, exclusive workflow to develop focused libraries for enzymes.


 

Fig. 1. The screening workflow of Receptor.AI

This approach involves comprehensive molecular simulations of the catalytic and allosteric binding pockets and ensemble virtual screening that accounts for their conformational flexibility. In the case of designing modulators, the structural adjustments caused by reaction intermediates are considered to improve activity and selectivity.


Key features that set our library apart include:


  • The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.

  • The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.

  • With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.

  • Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.


PARTNER
Receptor.AI
 
UPACC
Q96CM3

UPID:
RUSD4_HUMAN

ALTERNATIVE NAMES:
RNA pseudouridylate synthase domain-containing protein 4

ALTERNATIVE UPACC:
Q96CM3; E9PML2; Q96K56

BACKGROUND:
The enzyme Pseudouridylate synthase RPUSD4, mitochondrial, functions beyond mitochondrial RNA processing, extending its activity to the nucleus where it regulates pre-mRNA splicing through pseudouridylation. This modification at splice sites directly influences mRNA splicing and 3'-end processing, highlighting its significance in gene expression regulation. The enzyme's involvement in both mitochondrial and nuclear RNA processing underscores its multifaceted role in cellular biology.

THERAPEUTIC SIGNIFICANCE:
Understanding the role of Pseudouridylate synthase RPUSD4, mitochondrial could open doors to potential therapeutic strategies.

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