Focused On-demand Library for Elongation factor Ts, mitochondrial

Focused On-demand Libraries - Receptor.AI Collaboration


Explore the Potential with AI-Driven Innovation

Our detailed focused library is generated on demand with advanced virtual screening and parameter assessment technology powered by the Receptor.AI drug discovery platform. This method surpasses traditional approaches, delivering compounds of better quality with enhanced activity, selectivity, and safety.


Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by Reaxense.


Contained in the library are leading modulators, each labelled with 38 ADME-Tox and 32 physicochemical and drug-likeness qualities. In addition, each compound is illustrated with its optimal docking poses, affinity scores, and activity scores, giving a complete picture.


We employ our advanced, specialised process to create targeted libraries.


 

Fig. 1. The screening workflow of Receptor.AI

By deploying molecular simulations, our approach comprehensively covers a broad array of proteins, tracking their flexibility and dynamics individually and within complexes. Ensemble virtual screening is utilised to take into account conformational dynamics, identifying pivotal binding sites located within functional regions and at allosteric locations. This thorough exploration ensures that every conceivable mechanism of action is considered, aiming to identify new therapeutic targets and advance lead compounds throughout a vast spectrum of biological functions.


Our library is unique due to several crucial aspects:


  • Receptor.AI compiles all relevant data on the target protein, such as past experimental results, literature findings, known ligands, and structural data, thereby enhancing the likelihood of focusing on the most significant compounds.

  • By utilizing advanced molecular simulations, the platform is adept at locating potential binding sites, rendering the compounds in the focused library well-suited for unearthing allosteric inhibitors and binders for hidden pockets.

  • The platform is supported by more than 50 highly specialized AI models, all of which have been rigorously tested and validated in diverse drug discovery and research programs. Its design emphasizes efficiency, reliability, and accuracy, crucial for producing focused libraries.

  • Receptor.AI extends beyond just creating focused libraries; it offers a complete spectrum of services and solutions during the preclinical drug discovery phase, with a success-dependent pricing strategy that reduces risk and fosters shared success in the project.


PARTNER
Receptor.AI
 
UPACC
P43897

UPID:
EFTS_HUMAN

ALTERNATIVE NAMES:
-

ALTERNATIVE UPACC:
P43897; B4E391; F5H2T7; Q561V7; Q8TBC2; Q9UQK0

BACKGROUND:
The mitochondrial Elongation factor Ts (EF-Ts, mitochondrial), with UniProt accession P43897, is integral to the protein synthesis machinery. By associating with the EF-Tu.GDP complex, it induces GDP to GTP exchange, a critical step in the translation process. Its role ensures the assembly of proteins necessary for cellular function.

THERAPEUTIC SIGNIFICANCE:
Understanding the role of Elongation factor Ts, mitochondrial could open doors to potential therapeutic strategies. Its involvement in Combined oxidative phosphorylation deficiency 3 suggests that targeting this protein could offer new avenues for treating mitochondrial diseases, emphasizing the importance of further research in this area.

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