Focused On-demand Library for Uridine 5'-monophosphate synthase

Focused On-demand Libraries - Receptor.AI Collaboration


Explore the Potential with AI-Driven Innovation

The focused library is created on demand with the latest virtual screening and parameter assessment technology, supported by the Receptor.AI drug discovery platform. This method is more effective than traditional methods and results in higher-quality compounds with better activity, selectivity, and safety.


Our selection of compounds is from a large virtual library of over 60 billion molecules. The production and distribution of these compounds are managed by Reaxense.


The library includes a list of the most promising modulators annotated with 38 ADME-Tox and 32 physicochemical and drug-likeness parameters. Also, each compound is presented with its optimal docking poses, affinity scores, and activity scores, providing a comprehensive overview.


Our top-notch dedicated system is used to design specialised libraries.


 

Fig. 1. The screening workflow of Receptor.AI

Our strategy employs molecular simulations to explore an extensive range of proteins, capturing their dynamics both individually and within complexes with other proteins. Through ensemble virtual screening, we address proteins' conformational mobility, uncovering key binding sites at both functional regions and remote allosteric locations. This comprehensive investigation ensures a thorough assessment of all potential mechanisms of action, with the goal of discovering innovative therapeutic targets and lead molecules across across diverse biological functions.


Key features that set our library apart include:


  • The Receptor.AI platform integrates extensive information about the target protein, such as historical experiments, academic research, known ligands, and structural insights, thereby increasing the likelihood of identifying highly relevant compounds.

  • The platform’s sophisticated molecular simulations are designed to discover potential binding sites, ensuring that our focused library is optimal for the discovery of allosteric inhibitors and binders for cryptic pockets.

  • With over 50 customisable AI models, verified through extensive testing in commercial drug discovery and research, Receptor.AI is efficient, reliable, and precise. These models are essential in the production of our focused libraries.

  • Receptor.AI not only produces focused libraries but also provides full services and solutions at every stage of preclinical drug discovery, with a success-based pricing structure that aligns our interests with the success of your project.

PARTNER
Receptor.AI
 
UPACC
P11172

UPID:
UMPS_HUMAN

ALTERNATIVE NAMES:
-

ALTERNATIVE UPACC:
P11172; B5LY68; B5LY72; O00758; O00759; O00760; Q16862; Q9H3Q2; Q9UG49

BACKGROUND:
The enzyme Uridine 5'-monophosphate synthase is central to pyrimidine nucleotide biosynthesis, facilitating the final steps needed to produce uridine monophosphate from orotate. Its role is fundamental in the synthesis of nucleotides, the building blocks of genetic material.

THERAPEUTIC SIGNIFICANCE:
Understanding the role of Uridine 5'-monophosphate synthase could open doors to potential therapeutic strategies. Its direct involvement in Orotic aciduria 1, a disorder marked by metabolic anomalies leading to anemia and developmental delays, positions it as a key target for drug discovery efforts aimed at correcting pyrimidine metabolism defects.

Looking for more information on this library or underlying technology? Fill out the form below and we will be in touch with all the details you need.


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